The functional relationship of Yap/Taz with autophagy functions in sarcopenia associated with aging

BACKGROUND: Muscle loss is one of the features associated with aging significant impacts on quality life. Yap/Taz, effectors Hippo pathway, was shown to regulate organ size and may be aging. We postulate that Yap/Taz modulation play a role in maintaining muscle fiber or mediating function autophagy during sarcopenia. OBJECTIVE: The research aim explore sarcopenia its relationship expression. Additionally, we also explored skeletal tissue METHODS: conducted experiments two groups rats kept at 16 80 weeks. Skeletal from soleus harvested, mRNA expression genes pathway were quantified. Immunoblotting done antibodies against proteins. Bafilomycin Verteporfin used C2C12 cell line elucidate interaction between Yap/Taz. RESULTS: Old found have smaller surface area increased Yap protein inhibition levels. However, did not affect muscle. CONCLUSIONS: With current evidence, paradoxically sarcopenia, this increase caused by decreased autophagic flux